Rapid early growth is associated with increased risk of childhood type 1 diabetes in various European populations.
ثبت نشده
چکیده
OBJECTIVE To confirm that early growth is associated with type 1 diabetes risk in European children and elucidate any role of infant feeding. RESEARCH DESIGN AND METHODS Five centers participated, each with a population-based register of type 1 diabetes diagnosed at <15 years of age. Control subjects were randomly chosen from population registers, schools, or polyclinics. Growth data were obtained from routine records and infant feeding information from parental questionnaire or interview. Patient/control subject differences in mean standard deviation score (SDS) were obtained for each center and pooled. Odds ratios (ORs) were pooled by the Mantel-Haenszel method, and logistic regression was used to adjust for confounders. RESULTS Growth data were available for 499 patients and 1,337 control subjects. Height and weight SDS were significantly increased among patients from 1 month after birth, the maximum differences of 0.32 (95% CI 0.14-0.50) and 0.41 (0.26-0.55), respectively, occurring between 1 and 2 years of age. Significant excesses in BMI SDS were observed from 6 months of age, with the largest difference of 0.27 (0.10, 0.44) evident between 1 and 2 years. Breast-feeding was associated with reduced disease risk, OR 0.75 (0.58-0.96). Introduction of cow's milk, formula, or solid foods before 3 months was not associated with significant risk elevation. CONCLUSION Increased early growth is associated with disease risk in various European populations. Any role of infant feeding in this association remains unclear.
منابع مشابه
Rapid Early Growth is Associated With Increased Risk of Childhood Type 1 Diabetes in Various European Populations
متن کامل
Session 7: Early nutrition and later health early developmental pathways of obesity and diabetes risk.
Size at birth and patterns of postnatal weight gain have been associated with adult risk for the development of type 2 diabetes in many populations, but the putative pathophysiological link remains unknown. Studies of contemporary populations indicate that rapid infancy weight gain, which may follow fetal growth restriction, is an important risk factor for the development of childhood obesity a...
متن کاملO14: Televiewing and Children’s Development
Participants will be introduced to the risks associated with excessive early childhood televiewing and develop an understanding of the current recommended guidelines for children’s television exposure. My research agenda in Montreal (Canada) addresses modifiable factors in early childhood that influence human development. From birth through the preschool years, exponential brain maturatio...
متن کاملP-167: Association between Pregnancy Dietary Iron Intake and Gestational Diabetes Mellitus
Background: Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications affecting approximately 7% of all pregnancies and up to 14% of pregnancies in high-risk populations. Although, dietary iron intake is one of preventive factors for Iron deficiency which leads to less preterm delivery, prematurity, and SGA but iron is a strong pro-oxidant and high body iron levels c...
متن کاملPathways of infant and childhood growth that lead to type 2 diabetes.
OBJECTIVE Although a link between small body size at birth and later type 2 diabetes has been repeatedly documented, less is known about the associations between the disease and growth during infancy. The aim of this study was to explore the pathways of infant and early growth that lead to type 2 diabetes in adult life. RESEARCH DESIGN AND METHODS We carried out a longitudinal study of 8760 s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Diabetes care
دوره 25 10 شماره
صفحات -
تاریخ انتشار 2002